Preimplantation Genetic Testing for Monogenic Disorders (PGT-M)

NxGen Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) can determine whether any specific genetic conditions you tested positive for are present in your IVF embryos. This will allow your IVF doctor to select only those unaffected by the disorder for transfer, drastically reducing the risk of having an affected child. This service is a follow-up screen for couples or individuals who have had NxGen carrier screening as recommended for them by their physician.

Preimplantation Genetic Testing for Monogenic Disorders (PGT-M)

What Is It?

After in vitro fertilization, a couple can effectively screen any resulting embryos for a single gene condition using PGT-M (preimplantation genetic testing for monogenic disorders). PGT-M is used to screen for genetic conditions such as cystic fibrosis, sickle cell anemia, Tay-Sachs disease, Fragile X syndrome, and spinal muscular atrophy (SMA). Since the Super Panel screens for these conditions, only couples who screen positive for the same genetic condition need to undergo PGT-M screening.

Who Should Take It?

• Couples whose carrier screening identify them as carriers of a genetic disease or disorder

Why NxGen?

By opting to use NxGen's PGT-M program, we can determine whether the specific genetic condition(s) a patient tested positive for are present in the IVF embryos. This will allow the IVF doctor to select only those unaffected by the disorder for the transfer, drastically reducing the risk of having an affected child. NxGen PGT-M can screen for over 120 genetic conditions and offers best-in-class accuracy.

References

  • Human Fertilization and Embryology Authority; Latest UK IVF figures: 2010 and 2011. Available: www.hfea.gov.uk/docs/HFEA_Fertility_Trends_and_Figures_2011_*_Annual_Register_Report.pdf:22-23. Accessed 11 February 2013.
  • Fragouli E. Wells D (2011) Aneuploidy in the human blastocyst. Cytogenet Genome Res 133(2-4): 149-159.
  • Ata B, Kaplan B, Danzer H, Glassner M, Opsah M, et al. (2012) Array CHG analysis shows that aneuploidy is not related to the number of embryos generated. Reprod Biomed Online 24(6):614-620.
  • Wells D, Delhanty JD (2000) Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. Mol Hum Reprod 6(11): 1055-1062.
  • Schoolcraft, WB, Katz-Jaffe MG. (2013) Comprehensive chromosome screening of trophectoderm with vitrification facilitates elective single-embryo transfer for infertile women with advanced maternal age. Feril Steril 100(3): 615-619.
  • Forman EJ, Hong KH, Ferry KM, Tao X, Taylor D, et al. (2013) In vitro fertilization with single euploid blastocyst transfer:a randomized controlled trial. Fertil Steril. 2013 Jul;100(1):100-7.e1.

Talk to a Genetic Counselor

As a NxGen client, you'll have access to personal genetic counselors who can help explain the results of your screens and provide insight on how to move forward. To schedule a personal conference to discuss your screen results, call (855) 776-9436. or click the link below.

Discuss Your Screening Results

Connect With Our Customer Care Center

Get answers to all your questions related to billing, insurance coverage, the status of your screening results, and more by calling us at (855) 776-9436 or clicking the link below.

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