What Does NxGen MDx Screen For?
We screen for up to 120 genetic disorders that can affect your pregnancy, the health of your baby, and your family's future. You can learn more about our various screens — and which sets of screens (or "panels") align with where you are in your reproductive journey.
Factor XI Deficiency/Hemophilia C
What Your Test Results Mean:
Testing results indicate that you are a carrier of factor XI deficiency, also known as hemophilia C. Factor XI carriers have an increased risk for mild bleeding. You and your partner or donor would both have to be carriers of factor XI deficiency for there to be an increased chance to have a child with symptoms; this is known as autosomal recessive inheritance. Carrier testing of your partner or donor is recommended in addition to consultation with a genetic counselor for a more detailed risk assessment.
We recommend that you share and discuss this information with all of your health care providers. Since this is an inherited gene change, this information may be helpful to share with family members as it may impact their family planning and their own personal clinical management.
Factor XI deficiency, also known as hemophilia C, is a mild inherited bleeding disorder. It is typically less severe than hemophilia types A and B because it rarely causes spontaneous bleeds; however, bleeding episodes may occur with trauma, certain types of surgery, and dental procedures. Individuals with factor XI deficiency are also prone to bruising and nosebleeds. Affected women often have heavy menstrual periods and can experience prolonged bleeding after childbirth.
Life expectancy is normal if proper precautions with surgeries are taken.
A variety of treatment options are available to prevent bleeding, including fresh frozen plasma (preferably pathogen-inactivated), factor XI concentrates, and antifibrinolytics, to name a few. Additionally, individuals with factor XI deficiency will benefit from referral to federally funded hemophilia treatment centers.
Talk to a Genetic Counselor
As a NxGen client, you'll have access to personal genetic counselors who can help explain the results of your screens and provide insight on how to move forward. To schedule a personal conference to discuss your screen results, call (855) 776-9436. or click the link below.Discuss Your Screening Results