Nephrotic Syndrome/Congenital Finnish Nephrosis
What Your Test Results Mean:
Carriers are not expected to show symptoms. You and your partner would both have to be carriers of nephrotic syndrome/congenital Finnish nephrosis for there to be an increased chance to have a child with symptoms; this is known as autosomal recessive inheritance. Carrier testing of your partner or donor is recommended in addition to consultation with a genetic counselor for a more detailed risk assessment.
Since this is an inherited gene change, this information may be helpful to share with family members as it may impact their family planning.
Disease Explained:
Nephrotic syndrome/congenital Finnish nephrosis is an inherited condition that prevents the kidneys from filtering protein out of the urine. Symptoms of the disease begin in the first days or weeks after birth. Infants are often born prematurely with a low birth weight. High levels of protein in the blood, combined with kidney failure, cause the body to swell with excess fluid. Frequent infections and potentially harmful blood clots can also develop.
Prognosis:
Prognosis is generally unfavorable without treatment. Intensive medical therapy combined with kidney transplantation greatly improves outcomes and survival. If left untreated, death usually occurs before the age of four years.
Treatment:
Treatment involves intensive medical therapy to control bacterial infections combined with kidney transplantation. Successful kidney transplantation offers a good opportunity for survival with an acceptable quality of life for affected individuals.